Hoving, J. C., Wilson, G. J. and Brown, G. D. (2014) Signalling C-Type lectin receptors, microbial recognition and immunity. Cellular Microbiology, 16(2), pp. 185-194. (doi: 10.1111/cmi.12249) (PMID:24330199) (PMCID:PMC4016756)
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Abstract
Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-inflammatory responses which are either protective or not during an infection. Understanding the role of CLRs in shaping anti-microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLRs in antifungal immunity.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wilson, Dr Gillian |
| Authors: | Hoving, J. C., Wilson, G. J., and Brown, G. D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Cellular Microbiology |
| Publisher: | Wiley-Blackwell Publishing |
| ISSN: | 1462-5814 |
| ISSN (Online): | 1462-5822 |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in Cellular Microbiology 16(2):185-194 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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