Importance of sustained and “tight” blood pressure control in patients with high cardiovascular risk

Meredith, P. A., Lloyd, S. M. , Ford, I. and Elliott, H. L. (2016) Importance of sustained and “tight” blood pressure control in patients with high cardiovascular risk. Blood Pressure, 25(2), pp. 74-82. (doi: 10.3109/08037051.2015.1127528)

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Abstract

A retrospective further analysis of the ACTION database evaluated the relationship between cardiovascular outcomes and the “quality” of the control of blood pressure (BP). The study population (n = 6287) comprised those patients with four BP measurements during year 1 subdivided according to the proportion of visits in which BP was controlled in relation to two BP targets: < 140/90mmHg and < 130/80 mmHg. Differences between the BP control groups for the major prespecified ACTION outcomes were investigated with Cox proportional hazards models. For all the prespecified cardiovascular endpoints the incidence declined as the proportion of visits with BP control increased. The greatest differences in outcomes between the different BP control groups were observed for the risk of stroke but were still apparent for all the other endpoints. For example, the risks for the primary outcome [hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.67 to 0.90] were significantly less in the group with <_75% of visits with BP control than in the group with < 25% of visits with BP control. There were no significant treatment-related differences. Retrospective analyses are not definitive but these results highlight the importance of the attainment of BP control targets and the consistency of BP control during long-term follow-up.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meredith, Dr Peter and Ford, Professor Ian and Lloyd, Miss Suzanne
Authors: Meredith, P. A., Lloyd, S. M., Ford, I., and Elliott, H. L.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Blood Pressure
Publisher:Taylor and Francis
ISSN:0803-7051
ISSN (Online):1651-1999

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