Turrell, L., Hutchinson, E. C. , Vreede, F. T. and Fodor, E. (2015) Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation. Journal of Virology, 89(2), pp. 1452-1455. (doi: 10.1128/JVI.02332-14) (PMID:25355893) (PMCID:PMC4300657)
Full text not currently available from Enlighten.
Abstract
In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by reversible phosphorylation.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by Medical Research Council (MRC) grants MR/K000241/1 (to E.F.) and G1100138 (to F.T.V.) and a BBSRC studentship (to L.T.) |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hutchinson, Dr Edward |
| Authors: | Turrell, L., Hutchinson, E. C., Vreede, F. T., and Fodor, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Journal of Virology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0022-538X |
| ISSN (Online): | 1098-5514 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details