Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M. , Stewart, W. , Condon, B., Muir, K.W. , Welch, G. and Forbes, K.P. (2016) Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study. Journal of Neuroimaging, 26(4), pp. 406-413. (doi: 10.1111/jon.12332) (PMID:26919134)
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Abstract
Background and Purpose Carotid artery atherosclerotic plaque composition may influence plaque stability and risk of thromboembolic events, and non-invasive plaque imaging may therefore permit risk stratification for clinical management. Plaque composition was compared using non-invasive in-vivo (3T) and ex-vivo (7T) MRI and histopathological examination. Methods Thirty three endarterectomy cross sections, from 13 patients, were studied. The datasets consisted of in-vivo 3T MRI, ex-vivo 7T MRI and histopathology. Semi-automated segmentation methods were used to measure areas of different plaque components. Bland- Altman plots and mean difference with 95% confidence interval were carried out. Results There was general quantitative agreement between areas derived from semi-automated segmentation of MRI data and histology measurements. The mean differences and 95% confidence bounds in the relative to total plaque area between 3T versus Histology were: fibrous tissue 4.99 % (-4.56 to 14.56), lipid-rich/necrotic core (LR/NC) with haemorrhage - 1.81% (-14.11 to 10.48), LR/NC without haemorrhage -2.43% (-13.04 to 8.17), and calcification -3.18% (-11.55 to 5.18). The mean differences and 95% confidence bounds in the relative to total plaque area between 7T and histology were: fibrous tissue 3.17 % (-3.17 to 9.52), LR/NC with haemorrhage -0.55% (-9.06 to 7.95), LR/NC without haemorrhage - 12.62% (-19.8 to -5.45), and calcification -2.43% (-9.97 to 4.73). Conclusions This study provides evidence that semi-automated segmentation of 3T/7T MRI techniques can help to determine atherosclerotic plaque composition. In particular, the high resolution of ex-vivo 7T data was able to highlight greater detail in the atherosclerotic plaque composition. High field MRI may therefore have advantages for in vivo carotid plaque MR imaging.
| Item Type: | Articles |
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| Additional Information: | This is the peer reviewed version of the following article: Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M., Stewart, W., Muir, K.W., Condon, B., Welch, G. and Forbes, K.P. (2016), Atherosclerotic Carotid Plaque Composition: A 3T and 7T MRI-Histology Correlation Study. Journal of Neuroimaging. doi: 10.1111/jon.12332, which has been published in final form at [10.1111/jon.12332]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Stewart, Dr William and Welch, Mr George and Condon, Professor Barrie and Holmes, Dr William and Muir, Professor Keith and Lopez Gonzalez, Dr Maria Del and Forbes, Dr Kirsten |
| Authors: | Lopez Gonzalez, M.R., Foo, S.Y., Holmes, W.M., Stewart, W., Condon, B., Muir, K.W., Welch, G., and Forbes, K.P. |
| Subjects: | Q Science > QC Physics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Neuroimaging |
| Publisher: | Wiley |
| ISSN: | 1051-2284 |
| ISSN (Online): | 1552-6569 |
| Published Online: | 25 February 2016 |
| Copyright Holders: | Copyright © 2016 American Society of Neuroimaging |
| First Published: | First published in Journal of Neuroimaging 26(4): 406-413 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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