Thiele, H. et al. (2016) Multivessel versus culprit lesion only percutaneous revascularization plus potential staged revascularization in patients with acute myocardial infarction complicated by cardiogenic shock: design and rationale of CULPRIT-SHOCK trial. American Heart Journal, 172, pp. 160-169. (doi: 10.1016/j.ahj.2015.11.006) (PMID:26856228)
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Abstract
Background In acute myocardial infarction complicated by cardiogenic shock (CS), up to 80% of patients present with multivessel coronary artery disease. Currently, the best revascularization strategy is unknown. Therefore, a prospective randomized adequately powered clinical trial is warranted. Study design The CULPRIT-SHOCK study is a 706-patient controlled, international, multicenter, randomized, open-label trial. It is designed to compare culprit lesion only percutaneous coronary intervention (PCI) with possible staged non-culprit lesion revascularization versus immediate multivessel PCI in patients with CS complicating acute myocardial infarction. Patients will be randomized in a 1:1 fashion to one of the two treatment arms. The primary efficacy endpoint of CULPRIT-SHOCK is 30-day mortality and severe renal failure requiring renal replacement therapy. Secondary outcome measures such as hemodynamic, laboratory, and clinical parameters will serve as surrogate endpoints for prognosis. Furthermore, an intermediate- and long-term follow-up at 6 and 12 months will be performed. Safety endpoints include the assessment of bleeding and stroke. Conclusions The CULPRIT-SHOCK trial will address the question of optimal revascularization strategy in patients with multivessel disease and acute myocardial infarction complicated by CS.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Oldroyd, Dr Keith and Briggs, Professor Andrew |
| Authors: | Thiele, H., Desch, S., Piek, J. J., Stepinska, J., Oldroyd, K., Serpytis, P., Montalescot, G., Noc, M., Huber, K., Fuernau, G., de Waha, S., Meyer-Saraei, R., Schneider, S., Windecker, S., Savonitto, S., Briggs, A., Torremante, P., Vrints, C., Schuler, G., Ceglarek, U., Thiery, J., and Zeymer, U. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care |
| Journal Name: | American Heart Journal |
| Publisher: | Elsevier |
| ISSN: | 0002-8703 |
| ISSN (Online): | 1097-6744 |
| Published Online: | 01 December 2015 |
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