On-line high-precision carbon position-specific stable isotope analysis: a review

Gauchotte-Lindsay, C. and Turnbull, S. M. (2016) On-line high-precision carbon position-specific stable isotope analysis: a review. Trends in Analytical Chemistry, 76, pp. 115-125. (doi: 10.1016/j.trac.2015.07.010)

Abstract

Since the first commercial availability of gas chromatographs coupled with a combustion furnace and an isotope ratio mass spectrometry in 1990, compound-specific stable isotope analysis of organic molecules has been at the origin of scientific breakthroughs in a wide range of research fields. The presence of non-reacting atoms, however, can mask changes in molecular stable isotopic signatures; position-specific isotope analysis (PSIA) is the study of intramolecular isotopic variations. After a brief consideration of the potential and prospect of this new level in isotopic studies, in this study, we review few existing custom-built systems for on-line PSIA using continuous flow isotope ratio mass spectrometry instrumentation and how researchers have addressed issues related to this technique. Molecular fragmentation processes observed and optimised for various molecules are also discussed for on-line PSIA, as it would provide information on their application to new compounds.

• Item Type: Articles
• Additional Information: This work was also funded by EPSRC awards EP/D013739/1 and EP/D013739/2, held at Strathclyde University.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Turnbull, Ms Stephanie and Gauchotte-Lindsay, Professor Caroline
• Authors: Gauchotte-Lindsay, C., and Turnbull, S. M.
• College/School: College of Science and Engineering > School of Engineering; College of Science and Engineering > School of Engineering > Infrastructure and Environment
• Journal Name: Trends in Analytical Chemistry
• Publisher: Elsevier Ltd.
• ISSN: 0165-9936
• ISSN (Online): 1879-3142
• Published Online: 04 November 2015
• Copyright Holders: Copyright © 2016 Elsevier
• First Published: First published in Trends in Analytical Chemistry 76:115-125
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
61644	1	On-line Position Specific Isotope Analysis Interface for Continuous Flow Isotope Ration Mass Spectrometry	Caroline Gauchotte-Lindsay	Royal Society (ROYSOC)	UNSPECIFIED	ENG - ENGINEERING INFRASTRUCTURE & ENVIR