Insight into B5-I spinal interneurons and their role in the inhibition of itch and pain

Chiang, M. C., Hachisuka, J. , Todd, A. J. and Ross, S. E. (2016) Insight into B5-I spinal interneurons and their role in the inhibition of itch and pain. Pain, 157(3), pp. 544-545. (doi:10.1097/j.pain.0000000000000474) (PMID:26716996)

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Abstract

The last few years have seen major advances in our understanding of spinal microcircuits that integrate somatosensory input, resulting in part from availability of mice that allow genetically defined neuronal populations to be marked or manipulated. However, a genetically defined population does not necessarily correspond to a functional population, and defining functional populations remains a major challenge. Here we begin to address this by focusing on a group of inhibitory interneurons in superficial dorsal horn. These have been variously identified as PrP-GFP,4,9 B5-I,6,7 or Dyn-cre2 neurons. However, it now appears that they represent largely overlapping populations stemming from a common lineage. Here, we summarize what is known about these neurons, and consider their roles in the inhibition of itch and pain.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hachisuka, Dr Junichi and Todd, Professor Andrew
Authors: Chiang, M. C., Hachisuka, J., Todd, A. J., and Ross, S. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Pain
Publisher:Lippincott Williams & Wilkins
ISSN:0304-3959
ISSN (Online):1872-6623
Copyright Holders:Copyright © 2016 Lippincott Williams & Wilkins
First Published:First published in Pain 157(3):544-545
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
627371Spinal inhibitory interneurons that suppress itchAndrew ToddMedical Research Council (MRC)MR/L003430/1INP - CENTRE FOR NEUROSCIENCE
569571Populations of inhibitory interneurons in the superficial dorsal horn of the spinal cord.Andrew ToddBiotechnology and Biological Sciences Research Council (BBSRC)BB/J0001082/1RI NEUROSCIENCE & PSYCHOLOGY