Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi: 10.1007/978-1-4615-5385-4_3) (PMID:9433508)
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Abstract
Hypertensive left ventricular hypertrophy (LVH) is a major independent risk factor for cardiovascular morbidity and mortality in human essential hypertension. It has been shown that LVH is a better predictor of coronary artery disease and stroke than high blood pressure itself, hyperlipidaemia and cigarette smoking1,2. The spontaneously hypertensive rat (SHR) and its close relative stroke-prone SHR (SHRSP) have been used as models of hypertensive LVH and have allowed us to develop a number of mechanistic and genetic studies which would not have been feasible in human essential hypertension.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Graham, Dr Delyth and Reid, Professor John and Hamilton, Dr Carlene and Dominiczak, Professor Anna and McPhaden, Dr Allan |
| Authors: | Dominiczak, A. F., Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D., Clark, J. S., McPhaden, A., Hamilton, C. A., and Reid, J. L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Advances in Experimental Medicine and Biology |
| Publisher: | Springer New York |
| ISSN: | 0065-2598 |
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