The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio

Nile, C.J. , Apatzidou, D.A., Awang, R.A., Riggio, M.P. , Kinane, D.F. and Lappin, D.F. (2016) The effect of periodontal scaling and root polishing on serum IL-17E concentrations and the IL-17A:IL-17E ratio. Clinical Oral Investigations, 20(9), pp. 2529-2537. (doi: 10.1007/s00784-016-1749-8) (PMID:26888221)

Abstract

Objectives: The serum IL-17A:IL-17E ratio has previously been demonstrated to be a clinical marker of periodontitis. The aim of this study was to determine the effects of non-surgical periodontal treatment on the serum IL-17A:IL-17E ratio. Materials and methods: Forty chronic periodontitis patients completed this study and received periodontal treatment comprising scaling and root planing plus ultrasonic debridement. Clinical data were recorded at baseline, 6 weeks (R1) after treatment completion (full-mouth or quadrant-scaling and root planing) and 25 weeks after baseline (R2). Serum samples were taken at each time point and cytokines concentrations determined by ELISA. Results: Following treatment, statistically significant reductions were noted in clinical parameters. However, IL-17A and IL-17E concentrations were significantly greater than baseline values before- and after-adjusting for smoking. The IL-17A:IL-17E ratio was lower at R1 and R2. Serum IL-6 and TNF levels were significantly lower at R1 only. Also exclusively at R1, serum IL-17A and IL-17E correlated positively with clinical parameters, while the IL-17A:IL-17E ratio correlated negatively with probing pocket depth and clinical attachment. Conclusion: Increased serum IL-17E and a reduced IL-17A:IL-17E ratio may be indicative and/or a consequence of periodontal therapy. Therefore, the role of IL-17E in periodontal disease progression and the healing process is worthy of further investigation. Clinical relevance: IL-17E may be a valuable biomarker to monitor the healing process following periodontal treatment as increased IL-17E levels and a reduced IL-17A:IL-17E ratio could reflect clinical improvements post-therapy. Therefore, monitoring serum IL-17E might be useful to identify individuals who require additional periodontal treatment.

• Item Type: Articles
• Additional Information: The project was supported by Funding from Tenovus Scotland (Registered charity number SC009675) Royal College of Physicians and Surgeons of Glasgow, 232–242 St. Vincent Street Glasgow G2 5RJ UK and The Oral and Dental Research Trust Leeds Dental Institute, Clarendon Way Leeds LS2 9 LU UK.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lappin, Dr David and Riggio, Professor Marcello and Nile, Dr Christopher
• Authors: Nile, C.J., Apatzidou, D.A., Awang, R.A., Riggio, M.P., Kinane, D.F., and Lappin, D.F.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Clinical Oral Investigations
• Publisher: Springer
• ISSN: 1432-6981
• ISSN (Online): 1436-3771
• Published Online: 18 February 2016
• Copyright Holders: Copyright © 2016 Springer
• First Published: First published in Clinical Oral Investigations 20(9):2529-2537
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.