Cost-effectiveness of HBV and HCV screening strategies – a systematic review of existing modelling techniques

Geue, C. , Wu, O. , Xin, Y. , Heggie, R., Hutchinson, S., Martin, N. K., Fenwick, E. and Goldberg, D. (2015) Cost-effectiveness of HBV and HCV screening strategies – a systematic review of existing modelling techniques. PLoS ONE, 10(12), e0145022. (doi: 10.1371/journal.pone.0145022) (PMID:26689908) (PMCID:PMC4686364)

Abstract

Introduction: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling framework. It is therefore difficult to compare cost-effectiveness results between studies. This systematic review aims to summarise and critically assess existing economic models for HBV and HCV in order to identify the main methodological differences in modelling approaches. Methods: A structured search strategy was developed and a systematic review carried out. A critical assessment of the decision-analytic models was carried out according to the guidelines and framework developed for assessment of decision-analytic models in Health Technology Assessment of health care interventions. Results: The overall approach to analysing the cost-effectiveness of screening strategies was found to be broadly consistent for HBV and HCV. However, modelling parameters and related structure differed between models, producing different results. More recent publications performed better against a performance matrix, evaluating model components and methodology. Conclusion: When assessing screening strategies for HBV and HCV infection, the focus should be on more recent studies, which applied the latest treatment regimes, test methods and had better and more complete data on which to base their models. In addition to parameter selection and associated assumptions, careful consideration of dynamic versus static modelling is recommended. Future research may want to focus on these methodological issues. In addition, the ability to evaluate screening strategies for multiple infectious diseases, (HCV and HIV at the same time) might prove important for decision makers.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Heggie, Mr Robert and Goldberg, Prof David and Fenwick, Professor Elisabeth and Xin, Miss Yiqiao and Wu, Professor Olivia and Geue, Dr Claudia
• Authors: Geue, C., Wu, O., Xin, Y., Heggie, R., Hutchinson, S., Martin, N. K., Fenwick, E., and Goldberg, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Copyright Holders: Copyright © 2015 2015 Geue et al.
• First Published: First published in PLoS ONE 10(12):e0145022
• Publisher Policy: Reproduced under a Creative Commons License