Freeman, S.P.H.T. , Bronk, C.R. and Hedges, R.E.M. (1990) The design of a radiocarbon muprobe for tracer mapping in biological specimens. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 52(3-4), pp. 405-409. (doi: 10.1016/0168-583X(90)90446-2)
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Abstract
Biological scientists use radioisotopes to label and subsequently monitor specific molecules within living systems. We aim to improve on conventional methods of imaging 14C tracers, in both sensitivity and resolution, by combining a new scanning-beam ion source generating C− secondary ions with our AMS system. Our measurements, including that of the generation of sufficient C− ions to the quantity of tissue sputtered, demonstrate that the radiocarbon muprobe is feasible, and we expect its sensitivity to be 1 14C label atom in 2000. We have employed the negative ion production enhancing effect of surface caesiation, investigating the potential of a Cs vapour spray for this purpose. As suitable Cs+ ion sources are unavailable, the muprobe will feature a Cs spray to compensate for the lack of primary beam surface caesiation, in conjunction with a 0.2 μm spot Ga+ beam.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Freeman, Professor Stewart |
| Authors: | Freeman, S.P.H.T., Bronk, C.R., and Hedges, R.E.M. |
| College/School: | College of Science and Engineering > Scottish Universities Environmental Research Centre |
| Journal Name: | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms |
| Publisher: | Elsevier |
| ISSN: | 0168-583X |
| ISSN (Online): | 1872-9584 |
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