Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P. , Russo, A., Maiello, F.M., Capasso, F. and Mascolo, N. (2002) Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia, 73(Supl 1), S38-S43. (doi: 10.1016/S0367-326X(02)00189-2) (PMID:12495708)

Abstract

We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maffia, Professor Pasquale
• Authors: Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P., Russo, A., Maiello, F.M., Capasso, F., and Mascolo, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Fitoterapia
• Publisher: Elsevier Science Inc.
• ISSN: 0367-326X