Carmody, R. J. and Chen, Y. H. (2007) Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling. Cellular and Molecular Immunology, 4(1), pp. 31-41.
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Abstract
Toll-like receptors (TLRs) recognize distinct microbial components to initiate the innate and adaptive immune responses. TLR activation culminates in the expression of appropriate pro-inflammatory and immunomodulatory factors to meet pathogenic challenges. The transcription factor NF-kappaB is the master regulator of all TLR-induced responses and its activation is the pivotal event in TLR-mediated activation of the innate immune response. Many of the key molecular events required for TLR-induced NF-kappaB activation have been elucidated. However, much remains to be learned about the ability of TLRs to generate pathogen-specific responses using a limited number of transcription factors. This review will focus on our current understanding of NF-kappaB activation by TLRs and potential mechanisms for achieving a signal-specific response through NF-kappaB.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Carmody, Dr Ruaidhri |
Authors: | Carmody, R. J., and Chen, Y. H. |
Subjects: | Q Science > Q Science (General) |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Cellular and Molecular Immunology |
Publisher: | Nature Publishing Group |
ISSN: | 1672-7681 |
ISSN (Online): | 2042-0226 |
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