Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent

Corea, G., Fattorusso, E., Lanzotti, V., Di Meglio, P., Maffia, P. , Grassia, G., Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48(22), pp. 7055-7062. (doi: 10.1021/jm050321r) (PMID:16250665)

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Abstract

From the whole plant of Euphorbia peplus L., a new diterpene based on a rare pepluane skeleton, named pepluanone (1), was isolated together with a known pepluane diterpene (2). The stereostructure of pepluanone was determined on the basis of an extensive NMR study, MS data, and chemical reaction. The ability of these compounds to act as antiinflammatory agents has been evaluated for the first time by in vivo tests on carrageenin-induced rat paw edema, an experimental model of acute inflammation. Comparison of the bioactivity of pepluanone and compound 2 in terms of chemical structure, evidenced the high efficiency of pepluanone and the absence of appreciable activity for compound 2, thus giving a first insight into the structure−activity relationship. Further in vitro experiments performed on pepluanone let us hypothesize that its activity could be explained in reducing the production of nitric oxide, prostaglandin E2, and TNF-α by inhibiting the expression of inducible nitric oxide synthase, cyclooxygenase-2, and TNF-α mRNA through the down-regulation of NF-κB binding activity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Professor Pasquale and Grassia, Dr Gianluca
Authors: Corea, G., Fattorusso, E., Lanzotti, V., Di Meglio, P., Maffia, P., Grassia, G., Ialenti, A., and Ianaro, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Medicinal Chemistry
Publisher:American Chemical Society
ISSN:0022-2623
ISSN (Online):1520-4804

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