Ayoub, A. , Roshan, C. P., Gillgrass, T., Naudi, K. and Ray, A. (2016) The clinical application of rhBMP-7 for the reconstruction of alveolar cleft. Journal of Plastic, Reconstructive and Aesthetic Surgery, 69(1), pp. 101-107. (doi: 10.1016/j.bjps.2015.09.004) (PMID:26507862)
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Abstract
In this study, radiographic assessment was performed to find out the effectiveness of bone regeneration following the application of recombinant human bone morphogenetic protein 7 (rhBMP-7) for the reconstruction of alveolar cleft defects in 11 cases: nine unilateral and two bilateral alveolar clefs. Reconstruction of the alveolar cleft was performed by using 3.5 mg of rhBMP-7 (Osigraft OP1) on a type I collagen carrier. Radiographs were taken 6 months post operation using a Gendex Intraoral Unit with Agfa Dentus M2 Comfort occlusal film. The amount of bony infill was graded on a Kindelan four-point scale. The patients were followed up for an average of 6.6 years. Based on the radiographic analysis, eight out of the nine unilateral alveolar cleft cases received a score of grade I and one patient had a grade II score, using the Kindelan scale. In the two bilateral alveolar clefts, only one side had bone formation. The radiographic appearance showed a normal trabecular pattern similar to the adjacent bone. Thus, rhBMP-7 was radiographically and clinically successful in regenerating the bone at the alveolar cleft which resulted in shortening of the operation time, absence of donor-site morbidity and a shorter hospital stay. The promising results of this preliminary study should encourage a phase II trial to compare bone grafts with BMP for the reconstruction of alveolar defects.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ayoub, Professor Ashraf and Gillgrass, Dr Toby |
| Authors: | Ayoub, A., Roshan, C. P., Gillgrass, T., Naudi, K., and Ray, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Journal of Plastic, Reconstructive and Aesthetic Surgery |
| Publisher: | Elsevier |
| ISSN: | 1748-6815 |
| ISSN (Online): | 1878-0539 |
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