Naszai, M. , Carroll, L. and Cordero, J. (2015) Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut. Insect Biochemistry and Molecular Biology, 67, pp. 9-14. (doi: 10.1016/j.ibmb.2015.05.016) (PMID:26024801)
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Abstract
Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches. The intestinal epithelium has a remarkable regenerative capacity, which has made it a prime paradigm for the study of stem cell-driven tissue self-renewal. The discovery of the presence of stem cells in the adult midgut of the fruit fly Drosophila melanogaster has significantly impacted our understanding of the role of stem cells in intestinal homeostasis. Here we will review the current knowledge of the main mechanisms involved in the regulation of tissue homeostasis in the adult Drosophila midgut, with a focus on the role of stem cells in this process. We will also discuss processes involving acute or chronic disruption of normal intestinal homeostasis such as damage-induced regeneration and ageing.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cordero, Professor Julia and Naszai, Mr Mate |
Authors: | Naszai, M., Carroll, L., and Cordero, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Insect Biochemistry and Molecular Biology |
Publisher: | Elsevier Ltd. |
ISSN: | 0965-1748 |
ISSN (Online): | 1879-0240 |
Copyright Holders: | Copyright © 2015 Elsevier Ltd. |
First Published: | First published in Insect Biochemistry and Molecular Biology 67:9-14 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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