Cell type-specific interactions of transcription factors with a housekeeping promoterin vivo

Stapleton, G. , Patrizia Somma, M. and Lavia, P. (1993) Cell type-specific interactions of transcription factors with a housekeeping promoterin vivo. Nucleic Acids Research, 21(10), pp. 2465-2471. (doi: 10.1093/nar/21.10.2465) (PMID:8389443) (PMCID:PMC309548)

Abstract

Mammalian housekeeping promoters represent a class of regulatory elements different from those of tissues-specific genes, lacking a TATA box and associated with CG-rich DNA. We have compared the organization of the housekeeping Htf9 promoter In different cell types by genomic footprinting. The sites of in vivo occupancy clearly reflected local combinations of tissue-specific and ublqitous binding factors. The flexibility of the Htf9 promoter in acting as the target of cell-specific combinations of factors may ensure ubiquitous expression of the Htf9-assoclated genes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Stapleton, Dr Genevieve
• Authors: Stapleton, G., Patrizia Somma, M., and Lavia, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Nucleic Acids Research
• Publisher: Oxford University Press
• ISSN: 0305-1048
• ISSN (Online): 1362-4962