T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange

Sipido, K. R., Acsai, K., Antoons, G., Bito, V. and MacQuaide, N. (2012) T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange. Advances in Experimental Medicine and Biology, 961, pp. 375-83. (doi: 10.1007/978-1-4614-4756-6_32) (PMID:23224896)

Abstract

The Na(+)/Ca(2+) exchanger (NCX) is a key regulator of intracellular Ca(2+) in cardiac myocytes, predominantly contributing to Ca(2+) removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca(2+) channels face ryanodine receptors (RyRs), the Ca(2+) release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca(2+) release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca(2+) events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca(2+) gradients at the level of the dyadic space.

• Item Type: Articles
• Additional Information: ISBN: 9781461447559
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: MacQuaide, Dr Niall
• Authors: Sipido, K. R., Acsai, K., Antoons, G., Bito, V., and MacQuaide, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Advances in Experimental Medicine and Biology
• Publisher: Springer New York
• ISSN: 0065-2598
• ISSN (Online): 2214-8019