Macfarlane, L., Morris, J. , Pratschke, K., Mellor, D. , Scase, T., McFarlane, M. and McLauchlan, G. (2016) Diagnostic value of neutrophil-lymphocyte and albumin-globulin ratios in canine soft tissue sarcoma. Journal of Small Animal Practice, 57(3), pp. 135-441. (doi: 10.1111/jsap.12435) (PMID:26712718)
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Abstract
OBJECTIVE: To investigate the ability of neutrophil-to-lymphocyte ratio and albumin-to-globulin ratio to differentiate soft tissue sarcoma from benign soft tissue tumours. METHODS: A retrospective study of pretreatment haematology and biochemistry in dogs diagnosed with soft tissue sarcoma or benign soft tissue tumours. The neutrophil-to-lymphocyte ratio and albumin-to- globulin ratio were compared between the two groups. In dogs diagnosed with soft tissue sarcoma, the relationship of neutrophil-to-lymphocyte ratio and albumin-to-globulin ratio to histological tumour grade (I to III) was assessed. RESULTS: In the dogs with soft tissue sarcoma (n=22), the neutrophil-to-lymphocyte ratio was significantly increased and the albumin-to-globulin ratio decreased compared to those with benign soft tissue tumours (n=14). The neutrophil-to-lymphocyte ratio and albumin-to globulin ratio were not useful as predictors of tumour grade in dogs diagnosed with soft tissue sarcoma. CLINICAL SIGNIFICANCE: Pretreatment neutrophil-to-lymphocyte ratio and albumin-to globulin ratio may aid with diagnosis and optimal treatment planning. Further investigation into their prognostic implications is warranted.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pratschke, Ms Kathryn and Scase, Dr Timothy and Morris, Professor Joanna and Mellor, Professor Dominic and McLauchlan, Mr Gerard |
| Authors: | Macfarlane, L., Morris, J., Pratschke, K., Mellor, D., Scase, T., McFarlane, M., and McLauchlan, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Small Animal Practice |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| ISSN: | 0022-4510 |
| ISSN (Online): | 1748-5827 |
| Published Online: | 29 December 2015 |
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