Fornace, K.M. , Abidin, T.R., Alexander, N., Brock, P. , Grigg, M.J., William, T., Menon, J., Drakeley, C.J. and Cox, J. (2016) Association between landscape factors and spatial patterns of plasmodium knowlesi Infections in Sabah, Malaysia. Emerging Infectious Diseases, 22(2), pp. 201-208. (doi: 10.3201/eid2202.150656) (PMID:26812373) (PMCID:PMC4734530)
|
Text
113746.pdf - Published Version 268kB |
Abstract
The zoonotic malaria species Plasmodium knowlesi has become the main cause of human malaria in Malaysian Borneo. Deforestation and associated environmental and population changes have been hypothesized as main drivers of this apparent emergence. We gathered village-level data for P. knowlesi incidence for the districts of Kudat and Kota Marudu in Sabah state, Malaysia, for 2008–2012. We adjusted malaria records from routine reporting systems to reflect the diagnostic uncertainty of microscopy for P. knowlesi. We also developed negative binomial spatial autoregressive models to assess potential associations between P. knowlesi incidence and environmental variables derived from satellite-based remote-sensing data. Marked spatial heterogeneity in P. knowlesi incidence was observed, and village-level numbers of P. knowlesi cases were positively associated with forest cover and historical forest loss in surrounding areas. These results suggest the likelihood that deforestation and associated environmental changes are key drivers in P. knowlesi transmission in these areas.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Fornace, Dr Kimberly and Brock, Dr Patrick |
| Authors: | Fornace, K.M., Abidin, T.R., Alexander, N., Brock, P., Grigg, M.J., William, T., Menon, J., Drakeley, C.J., and Cox, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Emerging Infectious Diseases |
| Publisher: | U.S. Department of Health and Human Services |
| ISSN: | 1080-6040 |
| ISSN (Online): | 1080-6059 |
| Copyright Holders: | Copyright © 2015 Centers for Disease Control and Prevention |
| First Published: | First published in Emerging Infectious Diseases 22:2 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information