Ultrasound-mediated targeted drug delivery generated by multifocal beam patterns: an in vitro study

Gourevich, D., Hertzberg, Y., Volovick, A., Shafran, Y., Navon, G., Cochran, S. and Melzer, A. (2012) Ultrasound-mediated targeted drug delivery generated by multifocal beam patterns: an in vitro study. Ultrasound in Medicine and Biology, 39(3), pp. 507-514. (doi: 10.1016/j.ultrasmedbio.2012.10.013) (PMID:23332815)

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Abstract

Ultrasound-mediated targeted drug delivery has been a subject for a dedicated research activity for several decades. Nevertheless, in vitro studies in this field of research are characterized by their inconsistencies. To improve the repeatability of such experiments, a novel approach of multifocal spot generation was investigated. A multifocal pattern of 16 spots was utilized using an iterative Gerchberg–Saxton algorithm. The pattern was applied to insonate a 96-well Petri dish plate using a clinically available planar-phased array transducer with approximately 1000 elements with a central frequency of 0.55 MHz. The pattern was acoustically characterized and applied to a monolayer of human breast cancer cell line in the 96-well plate. With the help of ultrasonic contrast agents, the intracellular drug uptake was increased by an average factor of 3.5 compared with the control group.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cochran, Professor Sandy
Authors: Gourevich, D., Hertzberg, Y., Volovick, A., Shafran, Y., Navon, G., Cochran, S., and Melzer, A.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Ultrasound in Medicine and Biology
Publisher:Elsevier
ISSN:0301-5629
ISSN (Online):1879-291X

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