Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)
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Abstract
No abstract available.The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4+ T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote human Th1 cell differentiation and how IL-33 polarizes Th1 cells is less understood. We assessed the ability of IL-33 to induce Th1 cell differentiation and IFN-γ production in vitro and in vivo. We report here that IL-33 alone had no ability in Th1 cell polarization. However it potentiated IL-12-mediated Th1 cell differentiation and IFN-γ production in TCR-stimulated murine and human CD4+ T cells in vitro and in vivo. IL-33 promoted Th1 cell development via MyD88 and synergized with IL-12 to enhance St2 and IL-12R expression in CD4+ T cells. These data therefore provide a novel mechanism for Th1 cell differentiation and optimal induction of a Type 1 response. Thus, IL-33 is capable of inducing IL-12-dependent Th1 cell differentiation in human and mouse CD4+ T cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Xu, Dr Damo and Komai-Koma, Dr Mousa and Kurowska-Stolarska, Professor Mariola and McSharry, Dr Charles |
Authors: | Komai-Koma, M., Wang, E., Kurowska-Stolarska, M., Li, D., McSharry, C., and Xu, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Immunobiology |
Publisher: | Elsevier |
ISSN: | 0171-2985 |
ISSN (Online): | 1878-327 |
Published Online: | 07 December 2015 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in Immunobiology 221(3):412-417 |
Publisher Policy: | Reproduced under a Creative Commons License |
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