Ferrero, D., Garriga, D., Navarro, A., Rodríguez, J., Verdaguer, N. and Sundquist, W. (2015) Infectious bursal disease virus VP3 upregulates VP1-mediated RNA-dependent RNA replication. Journal of Virology, 89(21), pp. 11165-11168. (doi: 10.1128/jvi.00218-15) (PMID:26311889)
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Abstract
Genome replication is a critical step in virus life cycles. Here, we analyzed the role of the infectious bursal disease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein complexes, on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp). Data show that VP3, as well as a peptide mimicking its C-terminal domain, efficiently stimulates the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3′ untranslated regions (UTRs) from the IBDV genome segments.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Navarro, Dr Aitor |
| Authors: | Ferrero, D., Garriga, D., Navarro, A., Rodríguez, J., Verdaguer, N., and Sundquist, W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Virology |
| Publisher: | American Society for Microbiology |
| ISSN: | 0022-538X |
| ISSN (Online): | 1070-6321 |
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