Huang, S. et al. (2015) Discovery of a single monooxygenase that catalyzes carbamate formation and ring contraction in the biosynthesis of the legonmycins. Angewandte Chemie (International Edition), 54(43), pp. 12697-12701. (doi: 10.1002/anie.201502902) (PMID:26206556)
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Abstract
Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization of the multifunctional FAD-dependent enzyme LgnC is now described. The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, and catalyze the biosynthesis of new bacterial PAs, the so-called legonmycins. By genome-driven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to originate from non-ribosomal peptide synthetases (NRPSs). The biosynthetic origin of bacterial PAs has thus been disclosed for the first time.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kelly, Dr Sharon |
Authors: | Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S. M., Trembleau, L., Ebel, R., Jaspars, M., Yu, Y., and Deng, H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Angewandte Chemie (International Edition) |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 1433-7851 |
ISSN (Online): | 1521-3773 |
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