McGinty, S. , McKee, S., Wadsworth, R. M. and McCormick, C. (2011) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28(1), pp. 1-29. (doi: 10.1093/imammb/dqq003)
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Abstract
In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mcginty, Dr Sean |
| Authors: | McGinty, S., McKee, S., Wadsworth, R. M., and McCormick, C. |
| College/School: | College of Science and Engineering > School of Engineering |
| Journal Name: | Mathematical Medicine and Biology |
| Publisher: | Oxford University Press |
| ISSN: | 1477-8599 |
| ISSN (Online): | 1477-8602 |
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