Rodgers, J. , Bradley, B., Kennedy, P. G.E. and Sternberg, J. M. (2015) Central nervous system parasitosis and neuroinflammation ameliorated by systemic IL-10 administration in trypanosoma brucei-Infected mice. PLoS Neglected Tropical Diseases, 9(10), e0004201. (doi: 10.1371/journal.pntd.0004201) (PMID:26505761) (PMCID:PMC4624684)
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Abstract
Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Bradley, Mrs Barbara and Rodgers, Dr Jean and Kennedy, Professor Peter |
Authors: | Rodgers, J., Bradley, B., Kennedy, P. G.E., and Sternberg, J. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | PLoS Neglected Tropical Diseases |
Publisher: | Public Library of Science |
ISSN: | 1935-2727 |
ISSN (Online): | 1935-2735 |
Copyright Holders: | Copyright © 2015 Rodgers et al. |
First Published: | First published in PLoS Neglected Tropical Diseases 9(10)e0004201 |
Publisher Policy: | Reproduced under a Creative Commons License |
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