Polymicrobial candida biofilms: friends and foe in the oral cavity

O'Donnell, L. E., Millhouse, E., Sherry, L. , Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

110863.pdf - Accepted Version



The role of polymicrobial biofilm infections in medicine is becoming more apparent. Increasing number of microbiome studies and deep sequencing has enabled us to develop a greater understanding of how positive and negative microbial interactions influence disease outcomes. An environment where this is particularly pertinent is within the oral cavity, a rich and diverse ecosystem inhabited by both bacteria and yeasts, which collectively occupy and coexist within various niches as biofilm communities. Studies within this environment have however tended to be subject to extensive independent investigation, in the context of either polymicrobial bacterial communities or yeast biofilms, but rarely both together. It is clear however that they are not mutually exclusive. Therefore, this review aims to explore the influence of candidal populations on the composition of these complex aggregates and biofilm communities, to investigate their mechanistic interactions to understand how these impact clinical outcomes, and determine whether we can translate how this knowledge can be used to improve patient management.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Sherry, Dr Leighann and Ramage, Professor Gordon and Malcolm, Dr Jennifer and Nile, Dr Christopher
Authors: O'Donnell, L. E., Millhouse, E., Sherry, L., Kean, R., Malcolm, J., Nile, C. J., Ramage, G., and Munro, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:FEMS Yeast Research
Publisher:Oxford University Press
ISSN (Online):1567-1356
Copyright Holders:Copyright © 2015 FEMS
First Published:First published in FEMS Yeast Research 15(7):fov077
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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