Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants

Peart, J. et al. (2002) Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants. Proceedings of the National Academy of Sciences of the United States of America, 99(16), pp. 10865-10869. (doi: 10.1073/pnas.152330599)

Abstract

Homologues of the yeast ubiquitin ligase-associated protein SGT1 are required for disease resistance in plants mediated by nucleotide-binding site/leucine-rich repeat (NBS-LRR) proteins. Here, by silencing SGT1 in Nicotiana benthamiana, we extend these findings and demonstrate that SGT1 has an unexpectedly general role in disease resistance. It is required for resistance responses mediated by NBS-LRR and other R proteins in which pathogen-derived elicitors are recognized either inside or outside the host plant cell. A requirement also exists for SGT1 in nonhost resistance in which all known members of a host species are resistant against every characterized isolate of a pathogen. Our findings show that silencing SGT1 affects diverse types of disease resistance in plants and support the idea that R protein-mediated and nonhost resistance may involve similar mechanisms.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sadanandom, Dr Ari
• Authors: Peart, J., Lu, R., Sadanandom, A., Malcuit, I., Moffett, P., Brice, D., Schauser, L., Jaggard, D., Xiao, S., Coleman, M., Dow, M., Jones, J., Shirasu, K., and Baulcombe, D.
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Proceedings of the National Academy of Sciences of the United States of America
• Publisher: National Academy of Sciences
• ISSN: 0027-8424
• ISSN (Online): 1091-6490