Murphy, D. J. and Muthalagu, N. (2015) BIM's up first. Molecular and Cellular Oncology, 2(2), e975083. (doi: 10.4161/23723556.2014.975083)
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Abstract
In vivo analysis of the genetic determinants of Myc-induced apoptosis reveals a specific requirement for the Bcl2 family protein Bim (Bcl2l11). Surprisingly, apoptosis induced by Myc in multiple solid tissues does not require p19Arf (Cdkn2a), whereas Puma (Bbc3) is required only in the context of sensitization by Myc to death induced by DNA damage.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Murphy, Professor Daniel |
Authors: | Murphy, D. J., and Muthalagu, N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Molecular and Cellular Oncology |
Publisher: | Taylor and Francis |
ISSN: | 2372-3548 |
ISSN (Online): | 2372-3556 |
Published Online: | 01 December 2014 |
Copyright Holders: | Copyright © 2015 The Authors |
First Published: | First published in Molecular & Cellular Oncology 2(2):e975083 |
Publisher Policy: | Reproduced under a Creative Commons License |
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