Attention modulates TMS-locked alpha oscillations in the visual cortex

Herring, J. D., Thut, G. , Jensen, O. and Bergmann, T. O. (2015) Attention modulates TMS-locked alpha oscillations in the visual cortex. Journal of Neuroscience, 35(43), pp. 14435-14447. (doi: 10.1523/JNEUROSCI.1833-15.2015) (PMID:26511236) (PMCID:PMC4623224)

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Cortical oscillations, such as 8–12 Hz alpha-band activity, are thought to subserve gating of information processing in the human brain. While most of the supporting evidence is correlational, causal evidence comes from attempts to externally drive (“entrain”) these oscillations by transcranial magnetic stimulation (TMS). Indeed, the frequency profile of TMS-evoked potentials (TEPs) closely resembles that of oscillations spontaneously emerging in the same brain region. However, it is unclear whether TMS-locked and spontaneous oscillations are produced by the same neuronal mechanisms. If so, they should react in a similar manner to top-down modulation by endogenous attention. To test this prediction, we assessed the alpha-like EEG response to TMS of the visual cortex during periods of high and low visual attention while participants attended to either the visual or auditory modality in a cross-modal attention task. We observed a TMS-locked local oscillatory alpha response lasting several cycles after TMS (but not after sham stimulation). Importantly, TMS-locked alpha power was suppressed during deployment of visual relative to auditory attention, mirroring spontaneous alpha amplitudes. In addition, the early N40 TEP component, located at the stimulation site, was amplified by visual attention. The extent of attentional modulation for both TMS-locked alpha power and N40 amplitude did depend, with opposite sign, on the individual ability to modulate spontaneous alpha power at the stimulation site. We therefore argue that TMS-locked and spontaneous oscillations are of common neurophysiological origin, whereas the N40 TEP component may serve as an index of current cortical excitability at the time of stimulation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Thut, Professor Gregor
Authors: Herring, J. D., Thut, G., Jensen, O., and Bergmann, T. O.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Journal of Neuroscience
Publisher:The Society for Neuroscience
ISSN (Online):1529-2401
Copyright Holders:Copyright © 2015 Herring et al.
First Published:First published in Journal of Neuroscience 35(43): 14435-14447
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
597911Natural and modulated neural communication: State-dependent decoding and driving of human Brain OscillationsGregor ThutWellcome Trust (WELLCOME)098434/Z/12/ZINP - CENTRE FOR COGNITIVE NEUROIMAGING