Gray, J.V. and Krause, S.A. (2007) Identifying in vivo pathways using genome-wide genetic networks. Biochemical Society Transactions, 35(Pt6), pp. 1538-1541. (doi: 10.1042/BST0351538) (PMID:18031262)
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Abstract
Synthetic genetic interactions occur between two genes when the double mutant displays a phenotype much more severe than does either single mutant alone. Global networks of such interactions are now being systematically determined, spearheaded by the budding yeast genome. Genetic interactions reflect in vivo relationships between gene products. Extracting that functional information from such genetic networks is now possible by exploiting and modifying the key concept of congruence. Here, we focus on synthetic genetic interactions between pairs of null mutations in non-essential yeast genes. We summarize how to identify biological pathways from these emerging networks, using illustrative examples.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gray, Professor Joseph and Krause, Dr Sue |
| Authors: | Gray, J.V., and Krause, S.A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Published Online: | 01 January 2007 |
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