The effects of hyperhydrating supplements containing creatine and glucose on plasma lipids and insulin sensitivity in endurance-trained athletes

Polyviou, T. P., Pitsiladis, Y. P., Celis-Morales, C. , Brown, B., Speakman, J. R. and Malkova, D. (2015) The effects of hyperhydrating supplements containing creatine and glucose on plasma lipids and insulin sensitivity in endurance-trained athletes. Journal of Amino Acids, 2015, 352458. (doi: 10.1155/2015/352458) (PMID:26167296) (PMCID:PMC4488253)

Abstract

The addition of carbohydrate (CHO) in the form of simple sugars to creatine (Cr) supplements is central. The study aimed to determine whether ingestion of glucose (Glu) simultaneously with Cr and glycerol (Cr/Gly) supplement is detrimental to plasma lipids of endurance-trained individuals and find out whether modification arising can be attenuated by replacing part of the Glu with alpha lipoic acid (Ala). Twenty-two endurance-trained cyclists were randomized to receive Cr/Gly/Glu (11.4 g Cr-H2O, 1 g Gly/kg BM, and 150 g Glu) or Cr/Gly/Glu/Ala (11.4 g Cr-H2O, 1 g Gly/kg BM, 100 g Glu, and 1 g Ala) for 7 days. Fasting concentration of TAG increased significantly (P < 0.01) after supplementation with Cr/Gly/Glu (before: 0.9 ± 0.2 mmol/L; after: 1.3 ± 0.4 mmol/L) and Cr/Gly/Glu/Ala (before: 0.8 ± 0.2 mmol/L; after: 1.2 ± 0.5 mmol/L) but changes were not different between the groups. Supplementation significantly (P < 0.05) increased the TAG to HDL-cholesterol ratio but had no effect on fasting concentration of total, HDL-, and LDL-cholesterol and insulin resistance. Thus, addition of Glu to Cr containing supplements enhances plasma TAG concentration and the TAG to HDL-cholesterol ratio and this enhancement cannot be attenuated by partial replacement of Glu with Ala.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Malkova, Dr Dalia and Celis, Dr Carlos and Polyviou, Dr Thelma
• Authors: Polyviou, T. P., Pitsiladis, Y. P., Celis-Morales, C., Brown, B., Speakman, J. R., and Malkova, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: Journal of Amino Acids
• Publisher: Hindawi Publishing Corporation
• ISSN: 2090-0104
• ISSN (Online): 2090-0112
• Copyright Holders: Copyright © 2015 The Authors
• First Published: First published in Journal of Amino Acids 2015:352458
• Publisher Policy: Reproduced under a Creative Commons License