Baskerville, T. A., Macrae, I. M., Holmes, W. M. and McCabe, C. (2015) The influence of gender on ‘tissue at risk’ in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism, 36(2), pp. 381-386. (doi: 10.1177/0271678X15606137) (PMID:26661149)
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Abstract
This is the first study to assess the influence of sex on the evolution of ischaemic injury and penumbra. Permanent middle cerebral artery occlusion was induced in male (n = 9) and female (n = 10) Sprague-Dawley rats. Diffusion-weighted imaging was acquired over 4 h and infarct determined from T2 images at 24 h post-permanent middle cerebral artery occlusion. Penumbra was determined retrospectively from serial apparent diffusion coefficient lesions and T2-defined infarct. Apparent diffusion coefficient lesion volume was significantly smaller in females from 0.5 to 4 h post permanent middle cerebral artery occlusion as was infarct volume. Penumbral volume, and its loss over time, was not significantly different despite the sex difference in acute and final lesion volumes.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by an award (Ref: NS-GU-122) from the Translational Medicine Research Collaboration – a consortium of the Universities of Aberdeen, Dundee, Edinburgh and Glasgow, Grampian, Tayside, Lothian and Greater Glasgow & Clyde NHS Health Boards, Scottish Enterprise and Wyeth Pharmaceuticals. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Macrae, Professor Mhairi and Holmes, Dr William and McCabe, Dr Chris and Baskerville, Dr Tracey |
| Authors: | Baskerville, T. A., Macrae, I. M., Holmes, W. M., and McCabe, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Journal of Cerebral Blood Flow and Metabolism |
| Publisher: | Nature Publishing Group |
| ISSN: | 0271-678X |
| ISSN (Online): | 1559-7016 |
| Copyright Holders: | Copyright © 2015 Nature Publishing Group |
| First Published: | First published in Journal of Cerebral Blood Flow and Metabolism 36(2):381-386 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher. |
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