Fagerholm, S. C., Lek, H. S. and Morrison, V. L. (2014) Kindlin-3 in the immune system. American Journal of Clinical and Experimental Immunology, 3(1), pp. 37-42. (PMID:24660120) (PMCID:PMC3960760)
|
Text
108398.pdf - Published Version Available under License Creative Commons Attribution Non-commercial. 436kB |
Publisher's URL: http://www.ajcei.us/AJCEI_V3N1.html
Abstract
Kindlin-3 is a member of the kindlin family of focal adhesion proteins which bind to integrin beta-chain cytoplasmic domains to regulate integrin function. In contrast to kindlin-1 and kindlin-2 proteins, kindlin-3 is expressed mainly in the hematopoietic system. Mutations in kindlin-3 result in the rare genetic disorder, leukocyte adhesion deficiency type III (LAD-III), which is characterized by bleeding and recurrent infections due to deficient beta1, beta2 and beta3 integrin activation in platelets and leukocytes. Here, we review the role of kindlin-3 in integrin activation and in different immune cell functions.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Morrison, Dr Vicky |
| Authors: | Fagerholm, S. C., Lek, H. S., and Morrison, V. L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | American Journal of Clinical and Experimental Immunology |
| Publisher: | E-Century Publishing Corporation |
| ISSN: | 2164-7712 |
| ISSN (Online): | 2164-7712 |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in American Journal of Clinical and Experimental Immunology 3(1):37-42 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details