Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P. and Robello, C. (2015) Bestatin induces specific changes in trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy, 59(5), pp. 2921-2925. (doi: 10.1128/AAC.05046-14) (PMID:25712359)
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Abstract
Proteases and peptidases in Trypanosoma cruzi are considered potential targets for antichagasic chemotherapy. We monitored changes in low-mass metabolites in T. cruzi epimastigotes treated with bestatin, a dipeptide metalloaminopeptidase inhibitor. After treatment, multiple dipeptides were shown to be increased, confirming in situ inhibition of the leucine aminopeptidase of T. cruzi (LAPTc) and probably other peptidases.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Creek, Dr Darren and Barrett, Professor Michael |
Authors: | Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P., and Robello, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Antimicrobial Agents and Chemotherapy |
Journal Abbr.: | Antimicrob Agents Chemother |
Publisher: | American Society for Microbiology |
ISSN: | 0066-4804 |
ISSN (Online): | 1098-6596 |
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