Pejchinovski, M., Hrnjez, D., Ramirez-Torres, A., Bitsika, V., Mermelekas, G., Vlahou, A., Zürbig, P., Mischak, H., Metzger, J. and Koeck, T. (2015) Capillary zone electrophoresis on-line coupled to mass spectrometry: a perspective application for clinical proteomics. Proteomics Clinical Applications, 9(5-6), pp. 453-468. (doi: 10.1002/prca.201400113) (PMID:25641766)
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Abstract
Clinical proteomics, a rapidly growing field, intends to use specific diagnostic proteomic/peptidomic markers for initial diagnosis or prognosis of the progression of various diseases. Analyses of disease-associated markers in defined biological samples can provide valuable molecular diagnostic information for these diseases. This approach relies on sensitive and highly standardized modern analytical techniques. In the recent years, one of these technologies, CZE online coupled to MS (CZE-MS), has been increasingly used for the detection of peptide biomarkers (<20 kDa) in body fluids such as urine. This review presents the most relevant urinary proteomic studies addressing the application of CZE-MS in clinically relevant biomarker research between the years 2006 and 2014.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mischak, Professor Harald |
| Authors: | Pejchinovski, M., Hrnjez, D., Ramirez-Torres, A., Bitsika, V., Mermelekas, G., Vlahou, A., Zürbig, P., Mischak, H., Metzger, J., and Koeck, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Proteomics Clinical Applications |
| Publisher: | Wiley |
| ISSN: | 1862-8346 |
| ISSN (Online): | 1862-8354 |
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