Mansouri, D. , McMillan, D.C. , Crearie, C., Morrison, D.S., Crighton, E.M. and Horgan, P.G. (2015) Temporal trends in mode, site and stage of presentation with the introduction of colorectal cancer screening: a decade of experience from the West of Scotland. British Journal of Cancer, 113, pp. 556-561. (doi: 10.1038/bjc.2015.230) (PMID:26158422)
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Abstract
background: Population colorectal cancer screening programmes have been introduced to reduce cancer-specific mortality through the detection of early-stage disease. The present study aimed to examine the impact of screening introduction in the West of Scotland. methods: Data on all patients with a diagnosis of colorectal cancer between January 2003 and December 2012 were extracted from a prospectively maintained regional audit database. Changes in mode, site and stage of presentation before, during and after screening introduction were examined. results: In a population of 2.4 million, over a 10-year period, 14 487 incident cases of colorectal cancer were noted. Of these, 7827 (54%) were males and 7727 (53%) were socioeconomically deprived. In the postscreening era, 18% were diagnosed via the screening programme. There was a reduction in both emergency presentation (20% prescreening vs 13% postscreening, P0.001) and the proportion of rectal cancers (34% prescreening vs 31% pos-screening, P0.001) over the timeframe. Within non-metastatic disease, an increase in the proportion of stage I tumours at diagnosis was noted (17% prescreening vs 28% postscreening, P0.001). conclusions: Within non-metastatic disease, a shift towards earlier stage at diagnosis has accompanied the introduction of a national screening programme. Such a change should lead to improved outcomes in patients with colorectal cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mansouri, Mr David and Horgan, Professor Paul and Morrison, Dr David and McMillan, Professor Donald |
| Authors: | Mansouri, D., McMillan, D.C., Crearie, C., Morrison, D.S., Crighton, E.M., and Horgan, P.G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | British Journal of Cancer |
| Publisher: | Nature Publishing Group |
| ISSN: | 0007-0920 |
| ISSN (Online): | 1532-1827 |
| Copyright Holders: | Copyright © 2015 Cancer Research UK |
| First Published: | First published in British Journal of Cancer 2015 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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