Dietary intake, FTOGenetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents

Qi, Q. et al. (2015) Dietary intake, FTOGenetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents. Diabetes, 64(7), pp. 2467-2476. (doi: 10.2337/db14-1629) (PMID:25720386)

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bailey, Dr Mark
• Authors: Qi, Q., Downer, M.K., Kilpeläinen, T.O., Taal, H. R., Barton, S.J., Ntalla, I., Standl, M., Boraska, V., Huikari, V., Kiefte-de Jong, J.C., Körner, A., Lakka, T.A., Liu, G., Magnusson, J., Okuda, M., Raitakari, O., Richmond, R., Scott, R.A., Bailey, M.E.S., Scheuermann, K., Holloway, J.W., Inskip, H., Isasi, C.R., Mossavar-Rahmani, Y., Jaddoe, V.W.V., Laitinen, J., Lindi, V., Melén, E., Pitsiladis, Y., Pitkänen, N., Snieder, H., Heinrich, J., Timpson, N.J., Wang, T., Yuji, H., Zeggini, E., Dedoussis, G.V., Kaplan, C., Wylie-Rosett, J., Loos, J.F., Hu, F.B., and Qi, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Diabetes
• Publisher: American Diabetes Association
• ISSN: 0012-1797
• ISSN (Online): 1939-327X
• First Published: 26/02/2015