Aging-induced stem cell mutations as drivers for disease and cancer

Adams, P. D., Jasper, H. and Rudolph, K. L. (2015) Aging-induced stem cell mutations as drivers for disease and cancer. Cell Stem Cell, 16(6), pp. 601-612. (doi: 10.1016/j.stem.2015.05.002) (PMID:26046760) (PMCID:PMC4509784)

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Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here we discuss possible explanations for age-associated increases in the initiation and/or progression of mutant stem/progenitor clones and highlight the roles of stem cell quiescence, replication-associated DNA damage, telomere shortening, epigenetic alterations, and metabolic challenges as determinants of stem cell mutations and clonal dominance in aging.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Professor Peter
Authors: Adams, P. D., Jasper, H., and Rudolph, K. L.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cell Stem Cell
Publisher:Elsevier Inc.
ISSN (Online):1875-9777
Copyright Holders:Copyright © 2015 Elsevier Inc
First Published:First published in Cell Stem Cell 16(6):601-612
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
625581Senescence-associated chromatin changes a barrier to tumor progression.Peter AdamsCancer Research UK (CAN-RES-UK)16566ICS - EPIGENETICS
510444Epigenetics of Aging and Age-associated diseases : Epigenetic regulation of senescence and agingPeter AdamsNational Institute of Health (USA) (NIH(US))7P01AG031862-02RI CANCER SCIENCES