Development and function of protective and pathologic memory CD4 T cells

Jaigirdar, S. A. and Macleod, M. K.L. (2015) Development and function of protective and pathologic memory CD4 T cells. Frontiers in Immunology, 6, 456. (doi: 10.3389/fimmu.2015.00456) (PMID:26441961) (PMCID:PMC4561815)

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Abstract

Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. Generated following an immune response, memory CD4 T cells retain pertinent information about their activation environment enabling them to make rapid effector responses upon reactivation. These responses can either benefit the host by hastening the control of pathogens or cause damaging immunopathology. Here, we will discuss the diversity of the memory CD4 T cell pool, the signals that influence the transition of activated T cells into that pool, and highlight how activation requirements differ between naïve and memory CD4 T cells. A greater understanding of these factors has the potential to aid the design of more effective vaccines and to improve regulation of pathologic CD4 T cells, such as in the context of autoimmunity and allergy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jaigirdar, Shafqat Ahrar and Macleod, Dr Megan
Authors: Jaigirdar, S. A., and Macleod, M. K.L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Frontiers in Immunology
Publisher:Frontiers
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Frontiers in Immunology 6:456
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
581051Molecular requirements for the induction of tolerance in activated and memory CD4 T cells.Paul GarsideArthritis Research UK (ARUK)19905III -IMMUNOLOGY
632301Control of T Cell retention at inflammatory sitesMegan MacLeodArthritis Research UK (ARUK)20339III -IMMUNOLOGY
632301Control of T Cell retention at inflammatory sitesMegan MacLeodArthritis Research UK (ARUK)20339III -IMMUNOLOGY