Relative contribution of P450c17 towards the acute cortisol response: lessons from sheep and goats

Hough, D. , Storbeck, K., Cloete, S.W.P., Swart, A.C. and Swart, P. (2015) Relative contribution of P450c17 towards the acute cortisol response: lessons from sheep and goats. Molecular and Cellular Endocrinology, 408, pp. 107-113. (doi: 10.1016/j.mce.2015.01.018) (PMID:25597634)

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The rapid release of cortisol from the adrenal cortex upon ACTH receptor activation plays an integral role in the stress response. It has been suggested that the quantitative control over adrenal steroidogenesis (quantity of total steroids produced) depends on the activities of cytochrome P450 side-chain cleavage and steroidogenic acute regulatory protein that supplies pregnenolone precursor to the pathway. The qualitative control (which steroids) then depends on the downstream steroidogenic enzymes, including cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17). In this review we focus on the relative contribution of P450c17 in the qualitative control of cortisol production with data collected from studies on South African Angora and Boer goats, as well as Merino sheep. Unique P450c17 genotypes were identified in these breeds with isoforms differing only with a couple of single amino acid residue substitutions. This review demonstrates how molecular and cellular differences relating to P450c17 activity can affect physiological and behavioural responses.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Hough, Dr Denise
Authors: Hough, D., Storbeck, K., Cloete, S.W.P., Swart, A.C., and Swart, P.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Molecular and Cellular Endocrinology
Publisher:Elsevier Ireland Ltd.
ISSN (Online):1872-8057

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