Metabolic scaling in solid tumours

Milotti, E., Vyshemirsky, V. , Sega, M., Stella, S. and Chignola, R. (2013) Metabolic scaling in solid tumours. Scientific Reports, 3, 1938. (doi: 10.1038/srep01938) (PMID:23727729) (PMCID:PMC3670262)

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Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. Recently, by combining the diffusion of oxygen, nutrients, and metabolites in the extracellular environment, and the internal motions that mix live and dead cells, we derived a growth law of solid tumours which is linked to parameters at the cellular level1. Here we use this growth law to obtain a metabolic scaling law for solid tumours, which is obeyed by tumours of different histotypes both in vitro and in vivo, and we display its relation with the fractal dimension of the distribution of live cells in the tumour mass. The scaling behaviour is related to measurable parameters, with potential applications in the clinical practice.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vyshemirsky, Dr Vladislav
Authors: Milotti, E., Vyshemirsky, V., Sega, M., Stella, S., and Chignola, R.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Scientific Reports 3:1938
Publisher Policy:Reproduced under a Creative Commons License

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