Mirchandani, A. S. and Salmond, R. J. (2015) Innate lymphoid cells in type 2 immune responses. Archivum Immunologiae et Therapiae Experimentalis, 63(3), pp. 161-167. (doi: 10.1007/s00005-014-0327-5) (PMID:25527135)
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Abstract
In recent years, several distinct innate lymphoid cell populations (ILC) have been characterized in mice and humans. Group 2 ILC function as a rapid responder population in type 2 immune responses. Thus, a wealth of data has implicated an important role for ILC2 in immunity to parasitic infection and in immune pathology in inflammatory and allergic responses. In this review, we describe recent progress in our understanding of the development and ontogeny of ILC2 populations and the mechanisms by which these cells function in a variety of infection and disease settings. Finally, we emphasize recent findings indicating functional interactions between these innate cells and their adaptive CD4+ Th2 cell counterparts.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mirchandani, Dr Ananda and Salmond, Dr Robert |
| Authors: | Mirchandani, A. S., and Salmond, R. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Archivum Immunologiae et Therapiae Experimentalis |
| Publisher: | Springer |
| ISSN: | 0004-069X |
| ISSN (Online): | 1661-4917 |
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