Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi: 10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)
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Abstract
Knowledge on neuropeptide receptor systems is integral to understanding animal physiology. Yet, obtaining general insight into neuropeptide signalling in a clade as biodiverse as the insects is problematic. Here we apply fluorescent analogues of three key insect neuropeptides to map renal tissue architecture across systematically chosen representatives of the major insect Orders, to provide an unprecedented overview of insect renal function and control. In endopterygote insects, such as Drosophila, two distinct transporting cell types receive separate neuropeptide signals, whereas in the ancestral exopterygotes, a single, general cell type mediates all signals. Intriguingly, the largest insect Order Coleoptera (beetles) has evolved a unique approach, in which only a small fraction of cells are targets for neuropeptide action. In addition to demonstrating a universal utility of this technology, our results reveal not only a generality of signalling by the evolutionarily ancient neuropeptide families but also a clear functional separation of the types of cells that mediate the signal.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cabrero, Mr Pablo and Dow, Professor Julian and Halberg, Dr Kenneth and Terhzaz, Dr Selim and Davies, Professor Shireen |
| Authors: | Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A., and Dow, J. A.T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Nature Communications |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2015 Macmillan Publishers Limited |
| First Published: | First published in Nature Communications 6:6800 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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