Endocrine therapy: defining the path of least resistance

Stone, A. and Musgrove, E. A. (2014) Endocrine therapy: defining the path of least resistance. Breast Cancer Research, 16, 101. (doi: 10.1186/bcr3659) (PMID:25928145) (PMCID:PMC4053240)

Abstract

One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling. In both endocrine-resistant disease and breast cancer stem cells, this is commonly caused by specific genetic lesions or amplification of key pathway components or both. These observations have generated two interesting hypotheses. Firstly, do these genetic anomalies provide clinically significant biomarkers predictive of endocrine resistance? Secondly, do tamoxifen-resistant breast cancer cells emerge from a stem-like cell population? New studies, published in Breast Cancer Research, raise the possibility that these hypotheses are intrinsically linked.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Musgrove, Dr Elizabeth
• Authors: Stone, A., and Musgrove, E. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Breast Cancer Research
• Publisher: Biomed Central
• ISSN: 1465-5411
• ISSN (Online): 1465-542X
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Breast Cancer Research 16:101
• Publisher Policy: Reproduced under a Creative Commons License