Predictors of admission and readmission to hospital for major depression: a community cohort study of 52,990 individuals

Innes, H., Lewsey, J. and Smith, D. J. (2015) Predictors of admission and readmission to hospital for major depression: a community cohort study of 52,990 individuals. Journal of Affective Disorders, 183, pp. 10-14. (doi: 10.1016/j.jad.2015.04.019) (PMID:25965693)

Abstract

Background Our current knowledge about predictors of admission and re-admission to hospital as a result of major depressive disorder (MDD) is limited. Here we present a descriptive analysis of factors which are associated with MDD hospitalisations within a large population cohort.<p></p> Methods We linked participants of the Scottish Health Survey (SHS) to historical and prospective hospital admission data. We combined information from the SHS baseline interview and historical hospitalisations to define a range of exposure variables. The main outcomes of interest were: (1) first time admission for MDD occurring after the SHS interview; and (2) readmission for MDD. We used Cox regression to determine the association between each predictor and each outcome, after adjusting for age, gender and deprivation quintile.<p></p> Results 52,990 adult SHS participants were included. During a median follow-up of 4.5 years per participant, we observed 530 first-time admissions for MDD. A relatively wide range of factors – encompassing social, individual health status, and lifestyle-related exposures – were associated with this outcome (p<0.05). Among the 530 participants exhibiting a de novo admission for MDD during follow-up, 118 were later re-admitted. Only older age (over 70) and a prior non-depression related psychiatric admission were associated with readmission for MDD.<p></p> Limtations MDD was defined using records of International Classification of Disease hospital discharge codes rather than formal diagnostic assessments.<p></p> Conclusion These findings have implications for mental health service organisation and delivery and should stimulate future research on predictive factors for admission and readmission in MDD.<p></p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Smith, Professor Daniel
• Authors: Innes, H., Lewsey, J., and Smith, D. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
• Journal Name: Journal of Affective Disorders
• Publisher: Elsevier BV
• ISSN: 0165-0327
• ISSN (Online): 1573-2517