Breast cancer risk reduction - is it feasible to initiate a randomised controlled trial of a lifestyle intervention programme (ActWell) within a national breast screening programme?

Anderson, A. S. et al. (2014) Breast cancer risk reduction - is it feasible to initiate a randomised controlled trial of a lifestyle intervention programme (ActWell) within a national breast screening programme? International Journal of Behavioral Nutrition and Physical Activity, 11, 156. (doi:10.1186/s12966-014-0156-2) (PMID:25516158) (PMCID:PMC4304617)

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Abstract

Background: Breast cancer is the most commonly diagnosed cancer and the second cause of cancer deaths amongst women in the UK. The incidence of the disease is increasing and is highest in women from least deprived areas. It is estimated that around 42% of the disease in post-menopausal women could be prevented by increased physical activity and reductions in alcohol intake and body fatness. Breast cancer control endeavours focus on national screening programmes but these do not include communications or interventions for risk reduction.<p></p> This study aimed to assess the feasibility of delivery, indicative effects and acceptability of a lifestyle intervention programme initiated within the NHS Scottish Breast Screening Programme (NHSSBSP).<p></p> Methods: A 1:1 randomised controlled trial (RCT) of the 3 month ActWell programme (focussing on body weight, physical activity and alcohol) versus usual care conducted in two NHSSBSP sites between June 2013 and January 2014. Feasibility assessments included recruitment, retention, and fidelity to protocol. Indicative outcomes were measured at baseline and 3 month follow-up (body weight, waist circumference, eating and alcohol habits and physical activity). At study end, a questionnaire assessed participant satisfaction and qualitative interviews elicited women’s, coaches, and radiographers’ experiences. Statistical analysis used Chi squared tests for comparisons in proportions and paired t tests for comparisons of means. Linear regression analyses were performed, adjusted for baseline values, with group allocation as a fixed effect.<p></p> Results: A pre-set recruitment target of 80 women was achieved within 12 weeks and 65 (81%) participants (29 intervention, 36 control) completed 3 month assessments. Mean age was 58 ± 5.6 years, mean BMI was 29.2 ± 7.0 kg/m2 and many (44%) reported a family history of breast cancer.<p></p> The primary analysis (baseline body weight adjusted) showed a significant between group difference favouring the intervention group of 2.04 kg (95% CI −3.24 kg to −0.85 kg). Significant, favourable between group differences were also detected for BMI, waist circumference, physical activity and sitting time. Women rated the programme highly and 70% said they would recommend it to others.<p></p> Conclusions: Recruitment, retention, indicative results and participant acceptability support the development of a definitive RCT to measure long term effects.<p></p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wyke, Professor Sally and Dobson, Dr Hilary and Brennan, Dr Graham and O'Carroll, Prof Ronan
Authors: Anderson, A. S., Macleod, M., Mutrie, N., Sugden, J., Dobson, H., Treweek, S., O'Carroll, R., Thompson, A., Kirk, A., Brennan, G., and Wyke, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Social Scientists working in Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:International Journal of Behavioral Nutrition and Physical Activity
Publisher:BioMed Central
ISSN:1479-5868
ISSN (Online):1479-5868
Copyright Holders:Copyright © 2014 Anderson et al
First Published:First published in International Journal of Behavioral Nutrition and Physical Activity 11:156
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
588581Working together to support active living and well-being (ACTWELL) in the health promoting health service - feasibility trial to reduce breast cancer risk factors.Sally WykeScottish Executive Health Department (SEHHD-CSO)CZH/4/745SPS - INST. OF HEALTH & WELLBEING