O'Dowd, A., O'Dowd, J.J., O'Dowd, J.J., MacFarlane, N., Abe, H. and Miller, D.J. (1992) Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods. Journal of Chromatography B: Biomedical Sciences and Applications, 577(2), pp. 347-53. (doi: 10.1016/0378-4347(92)80257-Q) (PMID:1400766)
Full text not currently available from Enlighten.
Abstract
The paper reports two analytical high-performance liquid chromatographic methods to detect and quantify cardiac-derived histidyl derivatives. Method A relies on relative hydrophobicities as a basis of separation. Method B is an ion-pairing method in which the compounds are eluted in an entirely different order. Fractions collected from method A have been co-eluted in admixture in method B with authentic reference compounds. Thus the existence of the following imidazole ring-containing compounds derived from heart have been confirmed: N-acetylhistidine, N-acetyl-1-methylhistidine, N-acetylcarnosine, N-acetylhomocarnosine, homocarnosine, anserine, carnosine, balenine. Compounds were found in both tissue samples and perfusates.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | MacFarlane, Professor Niall and O'Dowd, Dr John |
Authors: | O'Dowd, A., O'Dowd, J.J., O'Dowd, J.J., MacFarlane, N., Abe, H., and Miller, D.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre College of Medical Veterinary and Life Sciences > School of Life Sciences |
Journal Name: | Journal of Chromatography B: Biomedical Sciences and Applications |
Publisher: | Elsevier |
ISSN: | 1387-2273 |
ISSN (Online): | 1872-812X |
University Staff: Request a correction | Enlighten Editors: Update this record