Impact of maternal obesity on perinatal and childhood outcomes

Santangeli, L., Sattar, N. and Huda, S. H. (2015) Impact of maternal obesity on perinatal and childhood outcomes. Best Practice and Research: Clinical Obstetrics and Gynaecology, 29(3), pp. 438-448. (doi:10.1016/j.bpobgyn.2014.10.009) (PMID:25497183)

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Abstract

Maternal obesity is of major consequence, affecting every aspect of maternity care including both short- and long-term effects on the health of the offspring. Obese mothers are at a higher risk of developing gestational diabetes and pre-eclampsia, potentially exposing the foetus to an adverse intrauterine environment. Maternal obesity is linked to foetal macrosomia, resulting in increased neonatal and maternal morbidity. Foetal macrosomia is a result of a change in body composition in the neonate with an increase in both percentage fat and fat mass. Maternal obesity and gestational weight gain are associated with childhood obesity, and this effect extends into adulthood. Childhood obesity in turn increases chances of later life obesity, thus type 2 diabetes, and cardiovascular disease in the offspring. Further clinical trials of lifestyle and, potentially, pharmacological interventions in obese pregnant women are required to determine whether short- and long-term adverse effects for the mother and child can be reduced.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed and Huda, Dr Shahzya
Authors: Santangeli, L., Sattar, N., and Huda, S. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Best Practice and Research: Clinical Obstetrics and Gynaecology
Publisher:Elsevier
ISSN:1521-6934
ISSN (Online):1878-156X

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