CE-MS-based proteomics in biomarker discovery and clinical application

Pontillo, C., Filip, S., Borràs, D. M., Mullen, W. , Vlahou, A. and Mischak, H. (2015) CE-MS-based proteomics in biomarker discovery and clinical application. Proteomics Clinical Applications, 9(3-4), pp. 322-334. (doi: 10.1002/prca.201400115) (PMID:25641774)

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CE-MS is applied in clinical proteomics for both the identification of biomarkers of disease and assessment of biomarkers in clinical diagnosis. The analysis is reproducible, fast, and requires only small sample volumes. However, successful CE-MS analysis depends on several critical steps that can be consolidated as follows: (i) proper sample preparation and fractionation, (ii) application of suitable capillary coating and appropriate CE-MS interfaces, to ensure the reproducibility and stability of the analysis, and (iii) an optimized clinical and statistical study design to increase the chances for obtaining clinically relevant results. In this review, we cover all these aspects, and present several examples of the application of CE-MS in clinical proteomics.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Mullen, Dr Bill and Mischak, Professor Harald
Authors: Pontillo, C., Filip, S., Borràs, D. M., Mullen, W., Vlahou, A., and Mischak, H.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Proteomics Clinical Applications
ISSN (Online):1862-8354

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
593511SysVascChristian DellesEuropean Commission (EC)603288RI CARDIOVASCULAR & MEDICAL SCIENCES